Episode 4: Genetic Engineering

Is Gattaca becoming reality? Can tobacco be a night light? Is there any chance Danny can pronounce He Jiankui correctly? Some of these are certainly more likely than others. While genetic engineering continues to take hold of the forefront of scientific and medical advancement, it is becoming more and more important for everyone to understand the implications. Join hosts Shanti and Danny as they discuss what genetic engineering is, where it started, it’s perception, what the future may hold for this technology, and what that can mean for you on the next episode of Breaking Bad Science.

Rabin, R.C., Gabler, E.; Two Huge Covid-19 Studies are Retracted After Scientists Sound Alarms. New York Times. 04-Jun-2020. https://www.nytimes.com/2020/06/04/health/coronavirus-hydroxychloroquine.html

Joseph, A., Lancet, New England Journal Retract Covid-19 Studies, Including One That Raised Safety Concerns About Malaria Drugs. Stat News Health. 04-June-2020. https://www.statnews.com/2020/06/04/lancet-retracts-major-covid-19-paper-that-raised-safety-concerns-about-malaria-drugs/

Lorsey, J., Rayor, L., Carter, M.; Transgenic Pollen Harms Monarch Larvae. Nature. 399: 214. 20-May-1999. Doi: https://doi.org/10.1038/20338

Sears, M., Hellmich, R., Stanley-Horn, D., Oberhauser, K., Pleasants, J., Mattila, H., Siegfried, B., Dively, G.; Impact of Bt Corn Pollen on Monarch Butterfly Populations: A Risk Assessment. PNAS. 98:21 (11937 – 11942). 09-Oct-2001. Doi: https://doi.org/10.1073/pnas.211329998

Beyer, P., Al-Babili, S., Ye, X., Lucca, P., Schaub, P., Welsch, R., Potrykus, I.; Golden Rice: Introducing the B-Carotene Biosynthesis Pathway Into Rice Endosperm by Genetic Engineering to Defeat Vitamin A Deficiency. The Journal of Nutrition. 132:3 (506S – 510S). 01-Mar-2002. Doi: https://doi.org/10.1093/jn/132.3.506S

Funke, T., Han, H., Healy-Fried, M., Fischer, M., Schonbrunn, E.; Molecular Basis for the Herbicide Resistance of Roundup Ready Crops. PNAS. 103:35 (13010 – 13015). 29-Aug-2006. Doi: https://doi.org/10.1073/pnas.0603638103

Schmeck Jr., H.; Tobacco Plant With Firefly Gene Implant Grows. New York Times. A12. 07-Nov-1986. https://www.nytimes.com/1986/11/07/us/tobacco-plant-with-firefly-gene-implant-grows.html

Abdel-Aal, E.-S.M., Hucl, P., Sosulski, F.W.; Compsitional and Nutritional Characteristics of Spring Einkorn and Spelt Wheats. Cereal Chemistry. 72:6 (621 – 624). 23-Jan-1995.

Shewry, P., Hey, S.; Do “Ancient” Wheat Species Differ from Modern Bread Wheat in Their Contents of Bioactive Components. Journal of Cereal Science. 65: (236 – 243). Sep-2015. Doi: https://doi.org/10.1016/j.jcs.2015.07.014

Cohen, J.; Did CRISPR Help-or Harm-the First-Ever Gene-Edited Babies. Science Magazine. 01-Aug-2019. https://www.sciencemag.org/news/2019/08/did-crispr-help-or-harm-first-ever-gene-edited-babies

Zhang, F., Wen, Y., Guo, X.; CRISPR/Cas9 for Genome Editing: Progress, Implications, and Challenges. Human Molecular Genetics. 23:R1 (R40 – R46). 15-Sep-2014. Doi: https://doi.org/10.1093/hmg/ddu125

Yin, H., Xue, W., Anderson, D.; CRISPR-Cas: A Tool for Cancer Research and Therapeutics. Nature Reviews Clinical Oncology. 16: (281 – 295). 21-Jan-2019. Doi: https://doi.org/10.1038/s41571-019-0166-8

Bella, R., Kaminski, R., et. al.; Removal of HIV DNA by CRISPR from Patient Blood Engrafts in Humanized Mice. Molecular Therapy Nucleic Acids. 12: (275 – 282). 07-Sep-2018. Doi: https://doi.org/10.1016/j.omtn.2018.05.021

Nicoll, M., Proenςa, J., Efstathiou, S.; The Molecular Basis of Herpes Simplex Virus Latency. FEMS Microbiology Reviews. 36:3 (684 – 705). 10-Jan-2012. Doi: 10.1111/j.1574-6976.2011.00320.x

Robertson, H., Soto-Adames, F.N., Walden, K., Avancini, R., Lampe, D.; Chapter 16 – The Mariner Transposons of Animals: Horizontally Jumping Genes. Horizontal Gene Transfer (Second Edition). Academic Press. (173 – 185). 2002. Doi: https://doi.org/10.1016/B978-012680126-2/50021-9

Schuelke, M., Wagner, K., Stolz, L., Hübner, C., et. al.; Myostatin Mutation Associated with Gross Muscle Hypertrophy in a Child. New England Journal of Medicine. 350: (2682 – 2688). 24-Jun-2004. Doi: https://doi.org/10.1056/NEJMoa04093